The Interaction of Chloroquine with Nucleic Acids and Nucleoproteins
نویسندگان
چکیده
منابع مشابه
The interaction of a 9-aminoacridine derivative with nucleic acids and nucleoproteins.
The reversible interaction of a 9-aminoacridine derivative with the ribonucleic acid of yeast was reported in a preliminary paper (1). The present report is concerned with a study of the binding of 2-methoxy-6-chloro-9(l’-methyl-8’-diethylaminooctylamino)acridine (SN-12868)’ by the nucleoprotein and desoxypentose nucleic acid of beef spleen, and additional data are presented for the interaction...
متن کاملThe Chemistry of the Nucleic Acids and Nucleoproteins
Isolation of nucleoproteins.-Many methods for isolating nucleoproteins involve a stage, either during the extraction or more generally in the precipitation process, which is relatively drastic and may produce an alteration in the chemical and physical properties of the nucleoprotein ; thus the majority of preparations involve precipitation of the extracted material with hydrochloric or acetic a...
متن کاملInteraction of nucleic acids with the glycocalyx.
Mammalian cells resist the uptake of nucleic acids. The lipid bilayer of the plasma membrane presents one barrier. Here, we report on a second physicochemical barrier for uptake. To create a sensitive probe for nucleic acid-cell interactions, we synthesized fluorescent conjugates in which lipids are linked to DNA oligonucleotides. We found that these conjugates incorporate readily into the plas...
متن کاملThe Identification and Estimation of Pentose in Nucleic Acids and Nucleoproteins
Pentoses---A number of pentoses were examined by the carbazole procedure as previously described (1). The Evelyn photoelectric filter photometer (3) was again employed, with filters transmitting maximally at 660, 540, 520, and 420 rnp. In contrast to the color characteristics of the hexoses obtained after treatment with sulfuric acid and carbazole, the pentoses gave rise to colored solutions wh...
متن کاملstudy of dna interaction with ethylenediaminetetraacetic acid and sesamol food additives
برهمکنش dnaتیموس گاوی طبیعی (ct-dna) با اتیلن دی آمین تترااستات (edta)در بافرtris-hcl با 8/7 ph ( دراین ph،edta به نمک دی سدیم تبدیل می شود) وسسامول در بافر tris-hcl با4/7 ph مورد بررسی قرار گرفته است. edta و سسامول استفاده فراوانی در تکنولوژی غذایی و صنعت شیمیایی دارند. مدل اتصال dna مربوط بهedta بوسیله اسپکتروفتومتری جذب، دورنگ نمایی حلقوی(cd)، ویسکومتری وژل الکتروفورز بررسی شده است. طیفuv ...
15 صفحه اولذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1952
ISSN: 0021-9258
DOI: 10.1016/s0021-9258(18)38529-6